January 1, 1997Clinical and Experimental Hypertension
Central Nervous System Monoamine Neurotransmitter Turnover in Primary and Obesity-Related Human Hypertension
Why the study?
Does central nervous system norepinephrine turnover correlate with sympathetic nervous activation in patients with essential hypertension and heart failure?
Population
Patients with pure autonomic failure, healthy men, cardiac failure patients, and untreated patients with…
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Association in untreated hypertension is hypothesis-generating; leaves open any role in heart failure and precludes practice change.
Structured PICO
Does central nervous system norepinephrine turnover correlate with sympathetic nervous activation in patients with essential hypertension and heart failure?
P
Population
Patients with pure autonomic failure, healthy men, cardiac failure patients, and untreated patients with essential hypertension
I
Intervention
Administration of trimethaphan or intravenous clonidine in a subset of subjects
O
Outcome
Central nervous system norepinephrine turnover (estimated from jugular overflow of norepinephrine, MHPG, and DHPG) and muscle sympathetic nerve activitysurrogate
Central nervous system release of norepinephrine mediates increased sympathetic nerve firing in patients with essential hypertension and heart failure.
Cite This Study
Esler et al. (1997) studied this question.