April 1, 2005Journal of Cardiovascular Electrophysiology
Role of Streptomycin‐Sensitive Stretch‐Activated Channel in Chest Wall Impact Induced Sudden Death (Commotio Cordis)
Key result
Streptomycin did not significantly alter induced ventricular fibrillation compared to control (53% vs 32%, P=0.15) but reduced ST elevation (19 vs 61 mV, P=0.015) in a swine commotio cordis model.
Why the study?
Does streptomycin prevent induced ventricular fibrillation in a swine model of commotio cordis?
Population
12 swine in a commotio cordis model receiving precordial impacts with a baseball propelled at 40 mph
Comparison
Streptomycin 2-g intramuscularly prior to chest… vs Sterile water prior to chest impact
Design
Preclinical, randomized, blinded
Authors
Discussion
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Member takes
Implication
Does not support streptomycin for commotio cordis prevention; leaves open stretch-activated channel role in humans.
Structured PICO
Does streptomycin prevent induced ventricular fibrillation in a swine model of commotio cordis?
P
Population
12 swine (mean 17.1 +/- 2.5 kg) in a commotio cordis model receiving precordial impacts with a baseball propelled at 40 mph
I
Intervention
Streptomycin 2-g intramuscularly prior to chest impact
C
Comparator
Sterile water prior to chest impact
O
Outcome
Frequency of induced ventricular fibrillation (VF)surrogate
Pharmacological blockade of stretch-activated channels with streptomycin does not prevent ventricular fibrillation in a swine model of commotio cordis, though it reduces ST segment elevation.
Cite This Study
Garan et al. (2005) studied this question. Streptomycin did not significantly alter induced ventricular fibrillation compared to control (53% vs 32%, P=0.15) but reduced ST elevation (19 vs 61 mV, P=0.015) in a swine commotio cordis model.