July 26, 2006Journal of Cardiovascular Electrophysiology

Ventricular Fibrillation Induced by Stretch Pulse: Implications for Sudden Death Due to Commotio Cordis

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Why the study?

Does sudden myocardial stretch induce ventricular fibrillation in Langendorff perfused rabbit hearts?

Population

6 Langendorff perfused rabbit hearts

Design

Preclinical

Authors

FBFrank BodeKarlsruhe Institute of Technology MFMichael R. FranzElectrophysiology IWI. WilkeKrankenhaus Reinbek - Startseite

Discussion

Member takes

Implication

May explain commotio cordis VF; hypothesis-generating for human stretch-induced arrhythmia mechanisms.

Structured PICO

Does sudden myocardial stretch induce ventricular fibrillation in Langendorff perfused rabbit hearts?

Population

6 Langendorff perfused rabbit hearts

Intervention

Sudden myocardial stretch in the left ventricle using a fluid-filled balloon with increasing volume and pressure pulses applied at different times of the cardiac cycle

Outcome

Action potential morphologies and ventricular fibrillation (VF) inducibilitysurrogate

Sudden myocardial stretch during a vulnerable window of repolarization inhomogeneity can induce ventricular fibrillation, providing a mechanistic explanation for sudden death in commotio cordis.

Cite This Study

Bode et al. (2006) studied this question.

synapsesocial.com/papers/6a72b6a93ce530166bc35ddc https://doi.org/10.1111/j.1540-8167.2006.00547.x

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