Why the study?
Does acute left ventricular dilatation alter refractoriness and dispersion of ventricular fibrillation intervals in isolated normal rabbit hearts?
Does acute left ventricular dilatation alter refractoriness and dispersion of ventricular fibrillation intervals in isolated normal rabbit hearts?
Acute ventricular stretch decreases refractoriness and increases its spatial dispersion, providing a mechanistic basis for how ventricular dilatation predisposes to the maintenance of reentrant arrhythmias.
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Supports stretch as proarrhythmic in isolated hearts; leaves open translation to clinical ventricular arrhythmias.
Francis L. Burton (1998) studied this question.
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