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October 5, 2004Cardiovascular Research

Effect of remodelling, stretch and ischaemia on ventricular fibrillation frequency and dynamics in a heart failure model

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Why the study?

Does acute stretch and ischemia alter ventricular fibrillation dynamics differently in a heart failure model compared to normal hearts?

Population

16 sheep (8 with heart failure induced by rapid ventricular pacing for 4-6 weeks, 8 controls)

Comparison

Acute stretch and global ischemia during… vs Control sheep and baseline low intraventricular…

Design

Preclinical

Authors

JMJavier MorenoUniversidad de Los Andes, ChileАЗА. В. ЗайцевLomonosov Moscow State UniversityMWMichelle P. WarrenUniversity of Nebraska Medical Center

Discussion

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Overview

HF may blunt ischemia effects on VF dynamics; leaves open translation to human arrhythmia risk.

Structured PICO

Does acute stretch and ischemia alter ventricular fibrillation dynamics differently in a heart failure model compared to normal hearts?

P
Population
16 sheep (8 with heart failure induced by rapid ventricular pacing for 4-6 weeks, 8 controls)
I
Intervention
Acute stretch (high intraventricular pressure 25-30 mm Hg) and global ischemia (5 min) during ventricular fibrillation
C
Comparator
Control sheep (normal hearts) and baseline low intraventricular pressure (0-5 mm Hg)
O
Outcome
Maximum dominant frequency (DF(max)), singularity point (SP) density, and number of SP lasting more than one revolution (rotors)surrogate

Heart failure remodeling decreases ventricular fibrillation rate and increases organization, while attenuating the effects of acute ischemia on VF dynamics compared to normal hearts.

Cite This Study

Moreno et al. (2004) studied this question.

synapsesocial.com/papers/6a8bb3c9ae714cd733ca9d04https://doi.org/10.1016/j.cardiores.2004.09.006

Topics

Heart failureHFrEF treatment
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pacing-induced heart failure: a model to study the mechanism of disease progression and novel therapy in heart failure1999 · 89 citations
  2. 2Stretch-Activated Ion Channels in the Heart1997 · 288 citations
  3. 3Two Types of Ventricular Fibrillation in Isolated Rabbit Hearts2002 · 186 citations
  4. 4Wavebreak Formation During Ventricular Fibrillation in the Isolated, Regionally Ischemic Pig Heart2003 · 114 citations
  5. 5Distribution of Excitation Frequencies on the Epicardial and Endocardial Surfaces of Fibrillating Ventricular Wall of the Sheep Heart2000 · 238 citations