January 1, 1996Journal of Cardiovascular Electrophysiology

Effect of Sustained Load on Dispersion of Ventricular Repolarization and Conduction Time in the Isolated Intact Rabbit Heart

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Why the study?

Does sustained load alter electrophysiologic parameters in isolated rabbit hearts?

Structured PICO

Does sustained load alter electrophysiologic parameters in isolated rabbit hearts?

Population

10 isolated Langendorff-perfused rabbit hearts

Intervention

Sustained load (filling a latex balloon inside the left ventricle with 1.0 mL of fluid)

Comparator

Baseline recordings (balloon filled with a neutral volume of fluid)

Outcome

Electrophysiologic parameters including effective refractory period (ERP), monophasic action potential durations at 90% repolarization (APD90), dispersion of APD90, and longest activation timesurrogate

Sustained mechanical load in isolated rabbit hearts shortens ERP and APD90 while increasing APD90 dispersion and activation times, providing insight into stretch-induced arrhythmogenesis.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Supports stretch-induced arrhythmogenesis in rabbit hearts; leaves open translation to human AF or HF.

Cite This Study

Zabel et al. (1996) studied this question.

synapsesocial.com/papers/6a2082d9cd682a52c6f89cbd https://doi.org/10.1111/j.1540-8167.1996.tb00455.x

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