Key result
Abnormal peripheral vascular responses to exercise were significantly correlated with exercise hypotension in patients with hypertrophic cardiomyopathy (r=0.61, p<0.001).
Why the study?
Does abnormal peripheral vascular response to exercise correlate with exercise hypotension and clinical risk factors in patients with hypertrophic cardiomyopathy?
Population
103 consecutive patients with hypertrophic cardiomyopathy and 25 normal controls.
Comparison
Maximal symptom-limited supine bicycle exercise… vs Normal controls to define normal response, and…
Design
Cross-sectional
Authors
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Supports hemodynamic contribution to exercise risk in HCM; hypothesis-generating and should not yet change practice.
Observational (n=103)
Does abnormal peripheral vascular response to exercise correlate with exercise hypotension and clinical risk factors in patients with hypertrophic cardiomyopathy?
Effect estimate: r = 0.61
p-value: p=<0.001
Abnormal peripheral vascular responses to exercise correlate with exercise hypotension and are more common in younger HCM patients with a family history of sudden death, suggesting a hemodynamic mechanism for risk.
Counihan et al. (1991) conducted an observational in Hypertrophic cardiomyopathy (n=103). Supine bicycle and erect treadmill exercise testing vs. Normal controls / Normal vs abnormal forearm blood flow response was evaluated on Relation of abnormal peripheral vascular responses (forearm blood flow) to erect exercise blood pressure response (r = 0.61, p=<0.001). Abnormal peripheral vascular responses to exercise were significantly correlated with exercise hypotension in patients with hypertrophic cardiomyopathy (r=0.61, p<0.001).
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