Key result
Abnormal peripheral vascular responses to exercise were significantly correlated with exercise hypotension in patients with hypertrophic cardiomyopathy (r=0.61, p<0.001).
Why the study?
Does abnormal peripheral vascular response to exercise correlate with exercise hypotension and clinical risk factors in patients with hypertrophic cardiomyopathy?
Observational (n=103)
Does abnormal peripheral vascular response to exercise correlate with exercise hypotension and clinical risk factors in patients with hypertrophic cardiomyopathy?
Effect estimate: r = 0.61
p-value: p=<0.001
Abnormal peripheral vascular responses to exercise correlate with exercise hypotension and are more common in younger HCM patients with a family history of sudden death, suggesting a hemodynamic mechanism for risk.
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Supports hemodynamic contribution to exercise risk in HCM; hypothesis-generating and should not yet change practice.
Counihan et al. (1991) conducted an observational in Hypertrophic cardiomyopathy (n=103). Supine bicycle and erect treadmill exercise testing vs. Normal controls / Normal vs abnormal forearm blood flow response was evaluated on Relation of abnormal peripheral vascular responses (forearm blood flow) to erect exercise blood pressure response (r = 0.61, p=<0.001). Abnormal peripheral vascular responses to exercise were significantly correlated with exercise hypotension in patients with hypertrophic cardiomyopathy (r=0.61, p<0.001).
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