Key result
Non-obstructive HCM patients have a ~14 mm Hg higher peak exercise PCWP versus healthy controls.
Why the study?
Dyspnoea and reduced exercise capacity are common in HCM without LVOT obstruction, but the haemodynamic mechanisms contributing to these symptoms are poorly described.
Do patients with HCM without LVOT obstruction have abnormal haemodynamic responses to exercise compared to healthy controls?
Observational (n=121)
Do patients with HCM without LVOT obstruction have abnormal haemodynamic responses to exercise compared to healthy controls?
Absolute Event Rate: 32% vs 18%
p-value: p=<0.001
Patients with non-obstructive HCM exhibit significantly elevated left ventricular filling pressures even at low exercise workloads, which correlates with reduced exercise capacity.
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Suggests diastolic dysfunction limits exercise in non-obstructive HCM; extends evidence beyond obstructive physiology and is hypothesis-generating for targeted therapies.
Gudmundsdottir et al. (2025) conducted an observational in Hypertrophic cardiomyopathy without left ventricular outflow tract obstruction (n=121). Supine incremental exercise vs. Healthy controls was evaluated on Pulmonary capillary wedge pressure at peak exercise (p=<0.001). Patients with HCM without LVOT obstruction had significantly higher pulmonary capillary wedge pressure at peak exercise compared to healthy controls (32 vs 18 mm Hg, p<0.001).
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