Key result
Non-obstructive HCM shows a ~9 mmHg steeper exercise PAWP increase than obstructive disease.
Why the study?
Deciphering the relative contribution of dynamic LVOTO, LV diastolic dysfunction, and left atrial myopathy to exertional dyspnea in HCM may be clinically relevant.
Does hemodynamic adaptation to exercise differ between obstructive and non-obstructive hypertrophic cardiomyopathy patients?
Cross-Sectional (n=25)
Does hemodynamic adaptation to exercise differ between obstructive and non-obstructive hypertrophic cardiomyopathy patients?
Absolute Event Rate: 23% vs 14%
p-value: p=<0.05
Non-obstructive HCM patients display a steeper increase in left atrial pressure during exercise compared to obstructive HCM patients, suggesting more advanced left atrial myopathy, while LVOTO may paradoxically reduce during supine exercise in overt HOCM.
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May guide phenotype-specific dyspnea evaluation in HCM; leaves open targeted interventions pending larger studies.
Baratto et al. (2026) conducted a cross-sectional in Hypertrophic cardiomyopathy (n=25). Non-obstructive hypertrophic cardiomyopathy vs. Obstructive hypertrophic cardiomyopathy was evaluated on Increase in pulmonary artery wedge pressure (PAWP) during exercise (p=<0.05). During exercise, non-obstructive hypertrophic cardiomyopathy patients showed a steeper increase in pulmonary artery wedge pressure than those with obstructive disease (23±3 vs 14±3 mmHg; p<0.05).
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