Key result
In patients with acute myocardial infarction and TIMI grade III reperfusion, left ventricular end-diastolic volume index decreased from 108 to 93 ml/m2 at 6 months and was best predicted by combining initial volumes with 1-week perfusion defect size.
Why the study?
Does quantitative gated SPECT (QGS) just after reperfusion and at 1 week predict LV volumes and LVEF at 6 months in patients with AMI and TIMI grade III reperfusion?
Observational (n=48)
Yes
Does quantitative gated SPECT (QGS) just after reperfusion and at 1 week predict LV volumes and LVEF at 6 months in patients with AMI and TIMI grade III reperfusion?
Answers are grounded in this paper and cite their sources.
Early quantitative gated SPECT parameters combined with 1-week perfusion defect size can predict 6-month left ventricular volumes and ejection fraction in patients with AMI after successful PCI.
BACKGROUND: The scintigraphic perfusion defect size (DS) at 1 week after acute myocardial infarction (AMI) predicts remote left ventricular (LV) volumes and LV ejection fraction (LVEF). The present study examined whether LV volumes and LVEF 6 months after AMI may be better predicted by the combination of LV volumes and LVEF just after reperfusion, and DS at 1 week, after AMI in patients with Thrombolysis In Myocardial Infarction (TIMI) grade III reperfusion by percutaneous coronary intervention. METHODS AND RESULTS: In 48 patients with AMI and TIMI grade III reperfusion, quantitative gated SPECT (QGS) was performed just after reperfusion, and at 1 week and 6 months after AMI. LV end-diastolic volume index decreased (108+/-8 to 93+/-6 ml/m(2), p<0.05) and LVEF increased (44+/-3 to 50+/-2%, p<0.05) 6 months after AMI. In addition, they were better predicted by a combination of LV volumes and LVEF just after reperfusion and DS at 1 week after AMI. CONCLUSIONS: In AMI with TIMI grade III reperfusion, LV volumes and LVEF at 6 months after MI correlate with the values obtained just after reperfusion. Myocardial perfusion imaging combined with QGS at reperfusion may predict these late-phase parameters.
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Kaneko et al. (2008) conducted an observational in Acute myocardial infarction with TIMI grade III reperfusion (n=48). Quantitative gated SPECT (QGS) and myocardial perfusion imaging was evaluated on Change in left ventricular end-diastolic volume index (LVEDVI) at 6 months (p=<0.05). In patients with acute myocardial infarction and TIMI grade III reperfusion, left ventricular end-diastolic volume index decreased from 108 to 93 ml/m2 at 6 months and was best predicted by combining initial volumes with 1-week perfusion defect size.
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