Key result
Contrast-enhanced MDCT detected acute coronary syndrome with 100% sensitivity (95% CI, 49-100%) and 74% specificity, potentially saving 70% of unnecessary hospital admissions.
Why the study?
Does contrast-enhanced MDCT improve early and accurate triage of patients with acute chest pain, nondiagnostic ECG, and normal cardiac enzymes?
Observational (n=40)
Blinded to MDCT results
Does contrast-enhanced MDCT improve early and accurate triage of patients with acute chest pain, nondiagnostic ECG, and normal cardiac enzymes?
Contrast-enhanced MDCT demonstrates 100% sensitivity for detecting ACS in low-to-intermediate risk chest pain patients, potentially reducing unnecessary hospital admissions by 70%.
May support MDCT triage in low-risk chest pain; leaves open need for RCTs before practice change.
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Hoffmann et al. (2006) conducted an observational in Acute chest pain (n=40). Contrast-enhanced MDCT vs. Standard clinical care was evaluated on Presence of significant coronary artery stenosis (diameter reduction > 50%) for detection of ACS. Contrast-enhanced MDCT detected acute coronary syndrome with 100% sensitivity (95% CI, 49-100%) and 74% specificity, potentially saving 70% of unnecessary hospital admissions.
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