Long-Term Survival Benefits of Porcine versus Pericardial Bioprostheses in Elderly Patients Undergoing Isolated Aortic Valve Replacement: A 32-Year Study
Key result
Pericardial bioprostheses linked to ~9% higher 10-year survival versus porcine valves in elderly AVR.
- P<0.001
- n=1,480
Why the study?
Bioprostheses are the valves of choice for older patients with aortic valve disease, but the optimal tissue valve remains undetermined.
Does a pericardial bioprosthesis improve long-term survival compared to a porcine bioprosthesis in patients aged ≥65 years undergoing isolated aortic valve replacement?
Population
1480 patients 65 years of age and older undergoing isolated aortic valve replacement
Comparison
Carpentier-Edwards Porcine (n = 650) vs Pericardial (n = 830) bioprosthesis
Design
Propensity score-matched cohort study
Authors
Discussion
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Implication
Hypothesis-generating for pericardial over porcine valves in elderly AVR; prospective randomized trials needed before practice change.
Study Design
Type
Cohort (n=1,480)
Structured PICO
Does a pericardial bioprosthesis improve long-term survival compared to a porcine bioprosthesis in patients aged ≥65 years undergoing isolated aortic valve replacement?
P
Population
1,480 patients aged ≥65 years undergoing isolated aortic valve replacement from 1990 through 2005
I
Intervention
Pericardial bioprosthesis (n=830)
C
Comparator
Porcine bioprosthesis (n=650)
O
Outcome
Long-term survivalhard clinical
Main Result
Absolute Event Rate: 41.8% vs 32.6%
p-value: p=<0.001
In elderly patients undergoing isolated aortic valve replacement, pericardial bioprostheses demonstrated superior long-term survival compared to porcine bioprostheses without increasing perioperative mortality.
Cite This Study
Ebra et al. (2023) conducted a cohort in Aortic valve disease (n=1,480). Pericardial bioprosthesis vs. Porcine bioprosthesis was evaluated on Survival at 10 years (p=<0.001). Pericardial bioprostheses demonstrated superior long-term survival compared to porcine bioprostheses in elderly patients undergoing aortic valve replacement (10-year survival 41.8% vs 32.6%; p<0.001).