Porcine vs Bovine Bioprosthetic Aortic Valves: Long-Term Clinical Results
Key result
Porcine bioprosthetic valves were associated with improved long-term survival compared with bovine prostheses (HR 0.90; 95% CI 0.85-0.96), despite an increased risk of reoperation.
Why the study?
Although bovine bioprosthetic aortic valves have shown superior hemodynamics over porcine valves, conflicting results leave their long-term effect on survival unclear.
Does surgical aortic valve replacement with porcine bioprosthetic valves improve long-term survival compared to bovine bioprosthetic valves in patients undergoing AVR?
Population
12,845 patients undergoing surgical AVR with or without CABG in Sweden
Comparison
Porcine (n = 4198) vs bovine (n = 8647) bioprosthetic valves
Design
Population-based registry cohort study with inverse probability of treatment weighting
Authors
Discussion
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Member takes
Implication
May inform valve selection in surgical AVR; leaves open confirmation after adjustment for confounding and reoperation risk.
Study Design
Type
Cohort (n=12,845)
Multicenter
Yes
Structured PICO
Does surgical aortic valve replacement with porcine bioprosthetic valves improve long-term survival compared to bovine bioprosthetic valves in patients undergoing AVR?
P
Population
12,845 patients who underwent surgical aortic valve replacement with porcine or bovine bioprosthetic valves in Sweden from 1995 to 2012, followed for up to 15 years.
E
Exposure
Surgical aortic valve replacement with porcine bioprosthetic valves (n=4,198)
C
Comparator
Surgical aortic valve replacement with bovine bioprosthetic valves (n=8,647)
O
Outcome
Long-term survivalhard clinical
Main Result
Hazard Ratio: 0.9 (95% CI 0.85–0.96)
In patients undergoing surgical AVR, porcine bioprostheses are associated with slightly better long-term survival but a higher risk of reoperation compared to bovine bioprostheses.
Cite This Study
Persson et al. (2020) conducted a cohort in surgical aortic valve replacement (n=12,845). Porcine bioprosthetic valves vs. Bovine bioprosthetic valves was evaluated on mortality (HR 0.90, 95% CI 0.85-0.96). Porcine bioprosthetic valves were associated with improved long-term survival compared with bovine prostheses (HR 0.90; 95% CI 0.85-0.96), despite an increased risk of reoperation.