A reverse J-shaped association of leisure time physical activity with prognosis in patients with stable coronary heart disease: evidence from a large cohort with repeated measurements
Key result
Daily strenuous activity in stable CHD linked to ~136% higher CV mortality versus moderate activity.
- HR 2.36
- 95% CI 1.05 to 5.34
- n=1,038
Why the study?
Does the level of leisure time physical activity affect the risk of major cardiovascular events and mortality in patients with stable coronary heart disease?
Population
1038 subjects with stable coronary heart disease (CHD)
Comparison
Self-reported physical activity level vs Moderately frequent active patients
Design
Cohort
Follow-up
10 years
Authors
Discussion
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Member takes
Implication
Caution advised against daily strenuous activity in stable CHD; supports reverse J-curve but leaves optimal intensity open for trials.
Study Design
Type
Cohort (n=1,038)
Structured PICO
Does the level of leisure time physical activity affect the risk of major cardiovascular events and mortality in patients with stable coronary heart disease?
P
Population
1038 subjects with stable coronary heart disease (CHD)
I
Intervention
Self-reported physical activity level (frequency of strenuous leisure time physical activity assessed repeatedly)
C
Comparator
Moderately frequent active patients
O
Outcome
Major cardiovascular events, cardiovascular mortality, and all-cause mortalityhard clinical
Main Result
Effect estimate: HR 2.36 (95% CI 1.05 to 5.34)
In patients with stable CHD, physical activity shows a reverse J-shaped association with cardiovascular mortality, where both physical inactivity and daily strenuous physical activity are associated with increased risk.
Cite This Study
Mons et al. (2014) conducted a cohort in stable coronary heart disease (n=1,038). Leisure time physical activity vs. Moderately frequent active patients was evaluated on Major cardiovascular events, cardiovascular mortality, all-cause mortality (HR 2.36, 95% CI 1.05 to 5.34). Daily strenuous physical activity in patients with stable CHD was associated with increased cardiovascular mortality compared to moderate activity (HR 2.36; 95% CI 1.05 to 5.34).