Population
Neonatal cardiomyocytes and mice (cyclinG1 knockout models)
Comparison
Overexpression or inactivation of the cyclinG1… vs Control/wild-type cardiomyocytes and mice
Design
Preclinical
Authors
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Modulating cyclinG1 may alter overload-induced remodeling; leaves open any human therapeutic relevance.
CyclinG1 is a key regulator of cardiomyocyte polyploidy and multinucleation, particularly in the context of pressure overload and hypertrophy.
Liu et al. (2010) studied this question.
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