Key result
Mature mammalian cardiomyocytes exhibit multinucleation and polyploidy, which may integrate biochemical and mechanical information to influence gene expression and cardiac regeneration.
Why the study?
Controlling the ability of mature mammalian cardiomyocytes to replicate would provide a much-needed approach for restoring cardiac function in damaged hearts.
Population
Mature mammalian cardiomyocytes
Design
Review
Authors
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May enable regeneration of damaged hearts; leaves open which switches to target in mature CMs.
Understanding the mechanisms of cardiomyocyte multinucleation and polyploidy may provide insights into restoring cardiac function in damaged hearts.
Landim-Vieira et al. (2019) conducted a review in Cardiomyocyte multinucleation and polyploidy. Cardiomyocyte multinucleation and polyploidy was evaluated. Mature mammalian cardiomyocytes exhibit multinucleation and polyploidy, which may integrate biochemical and mechanical information to influence gene expression and cardiac regeneration.
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