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July 28, 2021Applied Physiology Nutrition and Metabolism

Effect of small vs large muscle mass endurance training on maximal oxygen uptake in organ transplanted recipients

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Key result

Single leg cycling increases VO2max ~14% in organ transplant recipients, matching double leg cycling.

  • P<0.001
  • n=33

Why the study?

The contribution of cardiovascular, central, and peripheral factors in improving VO2max after endurance training has never been quantified in heart, kidney, and liver transplant recipients.

Does single leg cycling endurance training improve maximal oxygen uptake compared to double leg cycling in organ transplanted recipients?

Population

33 transplant recipients (13 HTx, 11 KTx, and 9 LTx)

Comparison

24 sessions of SL-ET vs DL-ET

Follow-up

24 sessions

Authors

ATAlessio del TortoCCCarlo CapelliRPRoberto Peressutti

Discussion

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Member takes

Overview

May support single-leg cycling as alternative training in transplant recipients; hypothesis-generating for peripheral adaptations, needs randomized confirmation.

Structured PICO

Does single leg cycling endurance training improve maximal oxygen uptake compared to double leg cycling in organ transplanted recipients?

P
Population
33 organ transplanted recipients (13 heart transplant, 11 kidney transplant, and 9 liver transplant)
I
Intervention
Single leg cycling endurance training (SL-ET) for 24 sessions
C
Comparator
Double leg cycling endurance training (DL-ET) for 24 sessions
O
Outcome
Maximal oxygen uptake (DL-V̇O2max)surrogate

Main Result

Absolute Event Rate: 13.8% vs 18.6%

p-value: p=<0.001

Single leg cycling endurance training is as effective as double leg cycling in improving maximal oxygen uptake in organ transplant recipients, highlighting the role of peripheral factors in exercise limitation.

Cite This Study

Torto et al. (2021) studied Organ transplanted recipients (heart, kidney, liver) (n=33). Single leg cycling endurance training (SL-ET) vs. Double leg cycling endurance training (DL-ET) was evaluated on Maximal oxygen consumption (DL-VO2max) (p=<0.001). Single leg cycling endurance training increased VO2max by 13.8% (p<0.001) in organ transplant recipients, proving as effective as double leg cycling (18.6% increase, p<0.001).

synapsesocial.com/papers/6a0906e462c780efd627fbf2https://doi.org/10.1139/apnm-2020-0987
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Effect of Endurance Training on Pulmonary V˙O2 Kinetics in Solid Organs Transplanted Recipients2022 · 2 citations
  2. 2Maximal Exercise Testing in Single and Double Lung Transplant Recipients1992 · 206 citations
  3. 3Exercise Limitation in Recipients of Lung Transplants2004 · 51 citations
  4. 4Impact of Exercise Modalities on Peripheral and Central Components of Cardiorespiratory Capacity in Heart Transplantation Patients: A Systematic Review and Meta-Analysis2021 · 5 citations
  5. 5Comparative Effectiveness of Exercise Training Modalities in Heart Transplant Recipients: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials2025 · 4 citations