January 1, 2008Clinical Chemistry and Laboratory Medicine (CCLM)
Influence of acute physical exercise on emerging muscular biomarkers
Why the study?
Does a sub-maximal aerobic exercise influence the concentration of emerging muscular biomarkers in healthy trained males?
Population
10 healthy trained Caucasian males
Comparison
21-km run (sub-maximal aerobic exercise) vs Baseline (pre-run) values
Design
Cohort
Follow-up
24 hours
Authors
Discussion
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Member takes
Implication
Recent exercise may confound emerging muscle biomarker interpretation; leaves open their specificity for myocardial injury in active patients.
Structured PICO
Does a sub-maximal aerobic exercise influence the concentration of emerging muscular biomarkers in healthy trained males?
P
Population
10 healthy trained Caucasian males
I
Intervention
21-km run (sub-maximal aerobic exercise)
C
Comparator
Baseline (pre-run) values
O
Outcome
Variations in biomarkers (cTnI, myoglobin, CK-MB, GPBB, CAIII, H-FABP, IMA) measured before, immediately after, 3, 6, and 24 hours after the runsurrogate
Sub-maximal aerobic exercise significantly increases several emerging biomarkers of muscle damage (GPBB, CAIII, H-FABP) but not IMA or cTnI, indicating these emerging markers cannot safely rule out myocardial damage in patients with recent physical activity.
Cite This Study
Lippi et al. (2008) studied this question.