Key result
A false positive cardiac troponin I result (6.4 μg/L) was caused by a true macrotroponin containing IgG and cTnI fragments, which was only immunoreactive in the Abbott Architect immunoassay.
Population
A 35-year-old female presenting with tiredness, shortness of breath, and recent onset of chest pain, with…
Design
Case_report
Authors
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Macrotroponin interference warrants consideration in unexplained troponin elevations; this case leaves open assay-specific prevalence and detection strategies.
Case Report (n=1)
Clinicians should be aware of analytical interference by macrotroponin when troponin results are constantly elevated without clinical explanation.
Michielsen et al. (2011) conducted a case report in False positive cardiac troponin I (n=1). Polyethylene glycol precipitation and gel filtration chromatography was evaluated on Identification of interference causing elevated cTnI. A false positive cardiac troponin I result (6.4 μg/L) was caused by a true macrotroponin containing IgG and cTnI fragments, which was only immunoreactive in the Abbott Architect immunoassay.
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