April 1, 2002Clinical Chemistry
False-Positive Troponin I Attributed to a Macrocomplex
Population
1 patient, a 78-year-old Caucasian woman with a pacemaker, prior myocardial infarction, transient ischemic…
Design
Case_report
Follow-up
74 days
Authors
Discussion
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Member takes
Implication
Isolated cTnI elevation without clinical change may reflect IgG macrocomplex interference; this case leaves open the prevalence and optimal detection strategy.
Structured PICO
P
Population
1 patient, a 78-year-old Caucasian woman with a pacemaker, prior myocardial infarction, transient ischemic episodes, and mitral valve failure, admitted for chest pain and dyspnea.
O
Outcome
Identification of the cause of persistently elevated cardiac troponin I (cTnI)surrogate
This case highlights that persistently elevated cardiac troponin I without clinical worsening can be caused by a macrocomplex (cTnI-IgG), which can lead to erroneous clinical interpretation.
Cite This Study
Plebani et al. (2002) studied this question.