Key result
cMyC to cTnI ratio peaks early in type 1 MI, dropping ~79% over time.
Why the study?
Early triage of patients with acute myocardial infarction is limited by the slow release of cardiac troponins, necessitating repeat testing and causing delays in treatment.
Absolute Event Rate: 7.98% vs 1.71%
p-value: p=<0.01
Cardiac myosin-binding protein C (cMyC) rises more rapidly than cardiac troponin I in early type 1 myocardial infarction, suggesting potential utility for more rapid triage of acute chest pain.
No takes yet. Share an insight, caveat, or question.
Faster biomarkers may aid early AMI triage in chest pain; leaves open clinical utility pending validation studies.
Kaier et al. (2016) conducted a letter in Type 1 Myocardial Infarction (n=26). Cardiac myosin-binding protein C (cMyC) vs. Cardiac troponin I (cTnI) was evaluated on Ratio of cMyC to cTnI over time (p=<0.01). The ratio of cardiac myosin-binding protein C to cardiac troponin I in type 1 MI was highest at presentation (mean 7.98) and decreased significantly over time (P<0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: