Cardiac troponins I and T in patients with suspected acute coronary syndrome: a comparative study in a routine setting
Why the study?
Does cardiac troponin I differ from cardiac troponin T in diagnosing acute myocardial infarction in patients with suspected acute coronary syndrome?
Population
Patients with suspected acute coronary syndrome, including those diagnosed with acute myocardial infarction…
Comparison
Cardiac troponin I measurement vs Cardiac troponin T measurement
Design
Cohort
Follow-up
up to 5 months
Authors
Discussion
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Member takes
Implication
Comparable AMI diagnostic performance between cTnI and cTnT; leaves open whether cTnT's higher UAP rate alters management in observational cohorts.
Structured PICO
Does cardiac troponin I differ from cardiac troponin T in diagnosing acute myocardial infarction in patients with suspected acute coronary syndrome?
P
Population
Patients with suspected acute coronary syndrome, including those diagnosed with acute myocardial infarction (n=68), unstable angina pectoris, and no acute coronary syndrome (n=84).
I
Intervention
Cardiac troponin I (cTnI) measurement (Access, Sanofi Pasteur)
C
Comparator
Cardiac troponin T (cTnT) measurement (Elecsys, Boehringer Mannheim)
O
Outcome
Diagnostic performance for acute myocardial infarction (AMI)surrogate
cTnI and cTnT have comparable clinical performance for diagnosing AMI, though cTnT may be more frequently elevated in unstable angina.
Limitations
- Clinical significance of discordance in UAP could not be determined from this study
Cite This Study
Hetland et al. (1998) studied this question.