Key result
hs-cTnI yields comparable diagnostic accuracy to hs-cTnT for AMI but has inferior prognostic value.
Why the study?
Does hs-cTnI compared to hs-cTnT improve diagnostic accuracy for acute myocardial infarction and prognostic accuracy for all-cause mortality in patients presenting to the emergency department with acute chest pain?
Population
2,211 consecutive patients presenting to the emergency department (ED) with acute chest pain
Comparison
High-sensitivity cardiac troponin I vs High-sensitivity cardiac troponin T
Design
Cohort
Follow-up
mean 24 months
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May not yet guide troponin assay selection in ED chest pain; leaves open need for randomized outcome trials.
Observational (n=2,211)
Yes
Does hs-cTnI compared to hs-cTnT improve diagnostic accuracy for acute myocardial infarction and prognostic accuracy for all-cause mortality in patients presenting to the emergency department with acute chest pain?
Absolute Event Rate: 0.93% vs 0.92%
p-value: p=0.078
In patients presenting with acute chest pain, hs-cTnI offers superior diagnostic accuracy for early AMI, whereas hs-cTnT provides superior prognostic accuracy for all-cause mortality.
A 2013 study conducted an observational in acute chest pain (n=2,211). hs-cTnI (Abbott) vs. hs-cTnT (Roche) was evaluated on diagnostic accuracy for acute myocardial infarction (AUC) (p=0.078). High-sensitivity cardiac troponin I had slightly higher diagnostic accuracy for acute myocardial infarction than hs-cTnT (AUC 0.93 vs 0.92; p=0.078), while hs-cTnT had superior prognostic accuracy.
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