Key result
Cardiac troponin I degradation in STEMI patients revealed intact cTnI and a single degradation product as early as 90 minutes post-symptom onset, correlating with higher cTnI levels (P<0.001).
Why the study?
What is the time course of cardiac troponin I degradation in patients with acute STEMI?
Population
26 males hospitalized with acute ST-elevation myocardial infarction within 6 hours after onset of symptoms
Design
Cohort, randomized to 2 different thrombolytic drugs
Follow-up
3 hours (7 samples at 30 minutes intervals)
Authors
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Early cTnI degradation may aid STEMI timing assessment; leaves open whether products improve early diagnosis or risk stratification.
RCT (n=26)
Randomized
What is the time course of cardiac troponin I degradation in patients with acute STEMI?
Cardiac troponin I degradation begins as early as 90 minutes after STEMI symptom onset, with the extent of degradation correlating with infarct size and time to treatment.
Madsen et al. (2006) conducted an RCT in Acute ST-elevation myocardial infarction (STEMI) (n=26). Thrombolytic drugs was evaluated on Time course of cardiac troponin I (cTnI) degradation. Cardiac troponin I degradation in STEMI patients revealed intact cTnI and a single degradation product as early as 90 minutes post-symptom onset, correlating with higher cTnI levels (P<0.001).
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