Key result
Myoglobin and CK-MB provided the highest positive likelihood ratios for AMI within 2 hours of ED presentation, whereas cardiac troponins were beneficial for identifying AMI ≥ 6 hours after presentation.
Why the study?
Do cardiac troponin I and troponin T offer better early diagnostic efficiency for acute myocardial infarction compared to CK, CK-MB, and myoglobin in ED chest pain patients without ST-elevation?
Cohort (n=177)
No
Do cardiac troponin I and troponin T offer better early diagnostic efficiency for acute myocardial infarction compared to CK, CK-MB, and myoglobin in ED chest pain patients without ST-elevation?
Myoglobin and CK-MB are superior to cardiac troponins for the early (≤ 2 hours) screening of acute myocardial infarction in ED patients without ST-elevation, whereas troponins become beneficial ≥ 6 hours after presentation.
No takes yet. Share an insight, caveat, or question.
May support myoglobin/CK-MB for very early AMI detection in ED; leaves open validation with hs-troponin assays.
Tucker et al. (1997) conducted a cohort in Acute myocardial infarction (n=177). Cardiac troponin I and troponin T vs. CK, CK-MB, and myoglobin was evaluated on Early diagnostic efficiency for acute myocardial infarction. Myoglobin and CK-MB provided the highest positive likelihood ratios for AMI within 2 hours of ED presentation, whereas cardiac troponins were beneficial for identifying AMI ≥ 6 hours after presentation.
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