Key result
Myoglobin outperforms other cardiac biomarkers for detecting AMI within two hours of ED admission.
Why the study?
To compare the early diagnostic efficiency of cTn-I, cTn-T, CK, CK-MB, and myoglobin for acute myocardial infarction in patients presenting without an initially diagnostic ECG within 24 hours of symptom onset.
What is the diagnostic efficiency of early cardiac biomarkers (Trop-I, Trop-T, CK, CK-MB, myoglobin) for acute myocardial infarction in patients presenting with chest pain and non-diagnostic ECG?
Population
140 chest pain patients aged >30 years without diagnostic initial ECG presenting within 24 hours
Comparison
cTn-I vs cTn-T vs CK vs CK-MB vs myoglobin levels
Design
Prospective observational cohort study
Follow-up
12-24 hours
Authors
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Supports further evaluation of novel biomarkers for AMI risk stratification; leaves open their incremental value over troponin in prospective trials.
Cohort (n=140)
No
What is the diagnostic efficiency of early cardiac biomarkers (Trop-I, Trop-T, CK, CK-MB, myoglobin) for acute myocardial infarction in patients presenting with chest pain and non-diagnostic ECG?
Myoglobin and CK-MB may offer superior early (<2 hours) diagnostic value compared to troponins for detecting acute myocardial infarction in patients with non-diagnostic ECGs, whereas troponins become more useful after 6 hours.
Cheema et al. (2021) conducted a cohort in Acute myocardial infarction (n=140). Serial cardiac biomarker testing (Trop-I, Trop-T, CK, CK-MB, myoglobin) vs. Standard diagnostic evaluation was evaluated on Early diagnostic efficiency (sensitivity, specificity, predictive values) of cardiac biomarkers for acute myocardial infarction. Myoglobin demonstrated the highest combination of sensitivity, specificity, and negative predictive value for detecting acute myocardial infarction within 2 hours of emergency department admission compared to other cardiac biomarkers.
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