Key result
Myoglobin (likelihood ratio 8.06) and ECG were the best predictors of acute myocardial infarction within 4 hours of chest pain onset, while troponin T showed high sensitivity but lower specificity.
Why the study?
Does measurement of troponin T and myoglobin at admission improve early diagnosis of AMI compared to CK, CK-MB, and ECG in patients with suspected AMI?
Population
290 consecutive patients admitted for evaluation of a suspected acute myocardial infarction (AMI)
Comparison
Measurement of troponin T and myoglobin at… vs Measurement of CK, CK-MB activity, and ECG
Design
Cohort
Authors
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ECG likelihood ratios refine early AMI probability; leaves open incremental diagnostic value of troponin T or myoglobin over CK-MB.
Observational (n=290)
Does measurement of troponin T and myoglobin at admission improve early diagnosis of AMI compared to CK, CK-MB, and ECG in patients with suspected AMI?
Myoglobin is a superior early marker for detecting AMI within 4 hours of chest pain onset compared to troponin T, CK, CK-MB, and ECG.
Bakker et al. (1994) conducted an observational in Suspected acute myocardial infarction (n=290). Troponin T and myoglobin vs. CK, CK-MB activity, and ECG was evaluated on Detection of acute myocardial infarction as defined by WHO criteria. Myoglobin (likelihood ratio 8.06) and ECG were the best predictors of acute myocardial infarction within 4 hours of chest pain onset, while troponin T showed high sensitivity but lower specificity.
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