Why the study?
Do rapid assays for myoglobin, CK-MBmass, and troponin T accurately rule out acute myocardial infarction in patients presenting with chest pain in the emergency room?
Population
309 consecutive patients presenting with chest pain in the emergency room
Comparison
Rapid assays for cardiac markers vs Gold standard for AMI
Design
Cohort
Authors
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Myoglobin may aid early AMI rule-out 3-6h post-onset but 89% NPV warrants caution; leaves open prospective validation of rapid assays.
Do rapid assays for myoglobin, CK-MBmass, and troponin T accurately rule out acute myocardial infarction in patients presenting with chest pain in the emergency room?
Myoglobin is an earlier marker than CK-MBmass or troponin T for ruling out AMI between 3 and 6 hours after symptom onset, though its maximal NPV is only 89%.
Winter et al. (1995) studied this question.
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