Key result
Cardiac troponin T at 6 hours post-pain demonstrated high diagnostic accuracy for acute myocardial infarction (AUC 0.989; 95% CI 0.966-1.0), superior to CK-MB mass and DeltaCK-MB.
Why the study?
Does cardiac troponin T measurement at 6 hours post-pain improve diagnostic accuracy for acute myocardial infarction compared to CK-MB strategies in emergency department patients with undifferentiated chest pain?
Population
786 consecutive admissions to the Emergency Department with undifferentiated chest pain considered at low…
Comparison
Cardiac troponin T measurement at 6 hours… vs CK-MB mass measurement on admission, CK-MB mass…
Design
Cohort
Follow-up
72 hours
Authors
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Supports troponin T at 6 hours for AMI diagnosis in ED chest pain; hypothesis-generating and requires prospective validation versus modern assays.
Observational (n=786)
Does cardiac troponin T measurement at 6 hours post-pain improve diagnostic accuracy for acute myocardial infarction compared to CK-MB strategies in emergency department patients with undifferentiated chest pain?
Effect estimate: AUC 0.989 (95% CI 0.966-1.0)
Absolute Event Rate: 0.989% vs 0.939%
Cardiac troponin T measured at 6 hours post-pain provides superior diagnostic sensitivity for acute myocardial infarction compared to CK-MB mass and its rate of change.
Collinson et al. (2006) conducted an observational in Undifferentiated chest pain / rule out of acute myocardial infarction (n=786). Cardiac troponin T (cTnT) measurement at 6 hours post-pain vs. CK-MB mass and DeltaCK-MB measurement was evaluated on Diagnostic efficiency for acute myocardial infarction (Area Under the Curve) (AUC 0.989, 95% CI 0.966-1.0). Cardiac troponin T at 6 hours post-pain demonstrated high diagnostic accuracy for acute myocardial infarction (AUC 0.989; 95% CI 0.966-1.0), superior to CK-MB mass and DeltaCK-MB.
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