Key result
Circulating autoantibodies to cardiac troponin I or other troponin complex proteins were identified as a source of negative interference in cTnI immunoassays (P<=0.007).
Population
Serum samples with low and normal recovery of added cTnI (n=20; 10 low recovery, 10 normal recovery)
Comparison
Isolation and identification of interfering… vs Samples with normal cTnI recovery
Design
Preclinical
Authors
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May cause false-negative cTnI results in animals; leaves open relevance to human assays.
p-value: p=<=0.007
Circulating autoantibodies to the troponin complex can cause negative interference in cTnI immunoassays, which is critical to recognize to avoid false-negative diagnoses of myocardial injury.
Eriksson et al. (2005) studied Negative interference in cTnI immunoassays (n=20). Detection of troponin-specific autoantibodies vs. Samples with normal cTnI recovery was evaluated on Detection of troponin-specific autoantibodies in samples with low vs normal cTnI recovery (p=<=0.007). Circulating autoantibodies to cardiac troponin I or other troponin complex proteins were identified as a source of negative interference in cTnI immunoassays (P<=0.007).
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