Key result
Troponin autoantibodies target I-T-C complexes and may underestimate cTnI in ~10% of early AMI patients.
Observational (n=15)
Anti-cardiac troponin autoantibodies specifically target the ternary troponin complex, which may lead to the underestimation of total cTnI levels in the early stages of acute myocardial infarction when using TnAAbs-sensitive immunoassays.
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Requires caution interpreting early cTnI in AMI suspects; extends evidence on autoantibody assay interference.
Vylegzhanina et al. (2016) conducted an observational in Acute myocardial infarction (AMI) (n=15). TnAAbs-sensitive immunoassays was evaluated on Epitope specificity of TnAAbs and influence on cTnI immunodetection. Autoantibodies to cardiac troponins are specific to structural epitopes in the ternary I-T-C complex, which could underestimate total cTnI in 5%-10% of early AMI patients.
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