October 2, 2013Clinical Chemistry and Laboratory Medicine (CCLM)
Autoantibody prevalence with an improved immunoassay for detecting cardiac troponin-specific autoantibodies
Why the study?
Does a new cTnAAb assay improve the detection of cardiac troponin-specific autoantibodies compared to an old assay in patients with suspected MI?
Population
510 consecutive chest pain patients presenting to an emergency department with suspected myocardial infarction
Comparison
New sandwich-type cTnAAb assay based on… vs Old cTnAAb assay
Design
Cohort
Follow-up
12 months
Authors
Discussion
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Member takes
Implication
An improved immunoassay detects cardiac troponin-specific autoantibodies in nearly 10% of patients with suspected MI, highlighting a potential source of interference in standard cTnI assays.
Structured PICO
Does a new cTnAAb assay improve the detection of cardiac troponin-specific autoantibodies compared to an old assay in patients with suspected MI?
P
Population
510 consecutive chest pain patients presenting to an emergency department with suspected myocardial infarction
I
Intervention
New sandwich-type cTnAAb assay based on different cTnI epitopes
C
Comparator
Old cTnAAb assay
O
Outcome
Prevalence of cTnAAb and assay performance (sample-specific backgrounds and net signals)surrogate
An improved immunoassay detects cardiac troponin-specific autoantibodies in nearly 10% of patients with suspected MI, highlighting a potential source of interference in standard cTnI assays.
Cite This Study
Savukoski et al. (2013) studied this question.