Autoantibodies to Cardiac Troponin Associate with Higher Initial Concentrations and Longer Release of Troponin I in Acute Coronary Syndrome Patients
Key result
Cardiac troponin autoantibodies, present in 21% of cTnI-positive acute coronary syndrome patients, were associated with significantly higher and more prolonged troponin I release over 1 year.
Why the study?
Does the presence of cardiac troponin autoantibodies associate with higher and prolonged cTnI release in non-ST-elevation ACS patients?
Population
81 non-ST-elevation acute coronary syndrome (ACS) patients
Comparison
Presence of cardiac troponin (cTn) autoantibodies vs Absence of cardiac troponin (cTn) autoantibodies
Design
Cohort
Follow-up
1 year
Authors
Discussion
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Member takes
Implication
May signal greater injury in ACS but should not change practice; hypothesis-generating for autoantibody effects on troponin kinetics.
Study Design
Type
Cohort (n=81)
Structured PICO
Does the presence of cardiac troponin autoantibodies associate with higher and prolonged cTnI release in non-ST-elevation ACS patients?
P
Population
81 non-ST-elevation acute coronary syndrome (ACS) patients
I
Intervention
Presence of cardiac troponin (cTn) autoantibodies
C
Comparator
Absence of cardiac troponin (cTn) autoantibodies
O
Outcome
Cardiac troponin I (cTnI) concentrations at admission, 1 week, 3 months, and 12 monthssurrogate
The presence of cardiac troponin autoantibodies in non-ST-elevation ACS patients is associated with higher initial and persistently elevated cTnI concentrations over 1 year, suggesting larger myocardial damage.
Limitations
- The possible prognostic impact of these observations must be evaluated in larger clinical cohorts
- Small sample size (requires evaluation in larger clinical cohorts)
Cite This Study
Pettersson et al. (2009) conducted a cohort in Non-ST-elevation acute coronary syndrome (n=81). Cardiac troponin autoantibodies vs. Absence of cardiac troponin autoantibodies was evaluated on Cardiac troponin I (cTnI) concentrations and release duration. Cardiac troponin autoantibodies, present in 21% of cTnI-positive acute coronary syndrome patients, were associated with significantly higher and more prolonged troponin I release over 1 year.