Key result
Autoantibodies to cardiac troponin showed lowest mean recoveries for the cTnI midfragment (37% to 211%), and IgG4 was the most prevalent subclass, detected in 68% of cTnAAb-positive samples.
Observational (n=48)
Autoantibodies to cardiac troponin interfere with cTnI assays, particularly at the midfragment epitopes, suggesting that assays should use 3 or more unconventionally selected epitopes to avoid interference.
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May affect cTnI assay accuracy in autoantibody-positive patients; leaves open optimal epitope strategies for interference mitigation.
Savukoski et al. (2013) conducted an observational in Autoantibodies to cardiac troponin (n=48). Epitope specificity and IgG subclass analysis of cTnAAbs vs. cTnAAb-negative sera was evaluated on Recovery of troponin complex and IgG subclass distribution. Autoantibodies to cardiac troponin showed lowest mean recoveries for the cTnI midfragment (37% to 211%), and IgG4 was the most prevalent subclass, detected in 68% of cTnAAb-positive samples.
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