Key result
IgG autoantibodies reactive with cTnI were present in 12.7% of normal donors, with similar prevalence in cardiac, infectious, and autoimmune cohorts except the rheumatoid factor cohort (20.4%).
Population
N = 1930 plasma and serum samples from normal blood donors and cohorts characterized by clinical biomarkers…
Design
Cross-sectional
Authors
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Frequent in healthy donors; hypothesis-generating for natural polyspecificity but leaves diagnostic or pathogenic relevance open.
Cross-Sectional (n=1,930)
Absolute Event Rate: 20.4% vs 12.7%
Circulating IgG autoantibodies against cardiac troponin-I are prevalent in normal blood donors and various disease cohorts, suggesting they are naturally occurring and polyspecific.
Adamczyk et al. (2009) conducted a cross-sectional in Cardiac, infectious, and autoimmune diseases (n=1,930). Cardiac, infectious, or autoimmune diseases vs. Normal blood donors was evaluated on Prevalence of IgG autoantibodies reactive with cTnI. IgG autoantibodies reactive with cTnI were present in 12.7% of normal donors, with similar prevalence in cardiac, infectious, and autoimmune cohorts except the rheumatoid factor cohort (20.4%).
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