Key result
Polyethylene glycol mixing normalizes spuriously elevated cTnI by inactivating interfering antibodies.
Why the study?
Abnormal serum cardiac troponin levels can occur in patients without myocardial infarction due to interference from endogenous or circulating antibodies affecting immunoassay measurements.
Population
48-year-old man with hypercholesterolemia and obesity presenting with chest pain
Comparison
Standard cTnI assay vs cTnI assay after polyethylene glycol treatment to inactivate interfering antibodies
Design
Case report
Authors
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Alerts clinicians to antibody interference in unexplained troponin elevations; leaves open validation of PEG testing before broader adoption.
Case Report (n=1)
Endogenous antibodies can cause spuriously elevated cardiac troponin I levels, which can be corrected by treating the sample with polyethylene glycol.
Makaryus et al. (2007) conducted a case report in Falsely elevated cardiac troponin I (n=1). Polyethylene glycol treatment of blood sample was evaluated on Cardiac troponin I level. In a 48-year-old man with chest pain, spuriously elevated cardiac troponin I levels were normalized after mixing the blood with polyethylene glycol to inactivate interfering antibodies.
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