Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 15, 2018Baylor University Medical Center Proceedings

Immunological interference due to heterophile antibodies caused falsely elevated cardiac troponin I levels on the AccuTnI+3 assay, which was undetectable on the Elecsys assay.

View Full Paper
Ask AI
Bookmark
Share

Population

94-year-old man with a prior history of coronary artery disease presenting with altered mental status

Comparison

Testing with an alternative troponin assay vs Initial troponin assay

Design

Case_report

Key result

Immunological interference due to heterophile antibodies caused falsely elevated cardiac troponin I levels on the AccuTnI+3 assay, which was undetectable on the Elecsys assay.

Authors

MAMohamed AyanZGZaid GheithAAAneesha Ananthula

Discussion

Loading...

Member takes

Overview

Consider assay interference with discordant troponin results; this case leaves open assay standardization needs.

Study Design

Type

Case Report (n=1)

Structured PICO

P
Population
A 94-year-old man with a prior history of coronary artery disease who presented with altered mental status and was found to have persistently high troponin levels due to assay interference.
E
Exposure
Testing with an alternative troponin assay (Elecsys Troponin I Assay, Roche)
C
Comparator
Initial troponin assay (AccuTnI+3, Beckman Coulter)
O
Outcome
Identification of false-positive troponin resultsurrogate

Discordance between clinical presentation and elevated troponin levels should prompt investigation for false-positive results due to assay interference, such as heterophile antibodies.

Cite This Study

Ayan et al. (2018) conducted a case report in Falsely elevated cardiac troponin (n=1). Alternative troponin assay (Elecsys Troponin I Assay, Roche) vs. Locally used assay (AccuTnI+3, Beckman Coulter) was evaluated on Cardiac troponin level. Immunological interference due to heterophile antibodies caused falsely elevated cardiac troponin I levels on the AccuTnI+3 assay, which was undetectable on the Elecsys assay.

synapsesocial.com/papers/6a2146ab18635152c357d031https://doi.org/10.1080/08998280.2018.1440856
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Falsely elevated troponin: rare occurrence or future problem2016 · 16 citations
  2. 2False-positive troponin elevation due to an immunoglobulin-G-cardiac troponin T complex: a case report2020 · 21 citations
  3. 3False Positive Cardiac Troponin Results in Patients Without Acute Myocardial Infarction2006 · 58 citations
  4. 4False Positive Cardiac Troponin Results in Patients Without Acute Myocardial Infarction2006 · 8 citations
  5. 5Falsely Elevated Cardiac Troponin I Levels2007 · 31 citations