Key result
Autoantibodies to cTnI or cTnT occur in ~16% of normal blood donors.
Population
Normal blood donors (n=345) with frozen plasma or serum samples from the Abbott Laboratories specimen bank.
Design
Cross-sectional
Authors
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Autoantibodies to troponin in normal donors suggest possible assay interference; leaves open clinical impact on patient testing.
Cross-Sectional (n=345)
The presence of autoantibodies to both cTnI and cTnT in normal blood donors highlights the potential for analytical interference, warranting caution when interpreting discordant troponin values.
Adamczyk et al. (2010) conducted a cross-sectional in Normal blood donors (n=345). Autoantibodies to cardiac troponin I and T was evaluated on Positivity for autoantibodies to cardiac troponin I or T isoforms. Among normal blood donors, 15.9% were positive for autoantibodies to cardiac troponin I or T, and 10.9% of these positive samples contained both autoantibodies.
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