Evidence of Apoptosis in Arrhythmogenic Right Ventricular Dysplasia
Population
Autopsy specimens from the right ventricular myocardium of 8 patients with arrhythmogenic right ventricular…
Design
Case-control
Authors
Discussion
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Implication
Apoptosis may contribute to cell loss in ARVD; case-control data leave open causal role and therapeutic targeting.
Key Points
- This research investigates whether cell death by apoptosis contributes to the loss of myocardial cells in arrhythmogenic right ventricular dysplasia.
- Analyzed autopsy specimens from eight patients with arrhythmogenic right ventricular dysplasia and four normal subjects.
- Performed in situ end-labeling of fragmented DNA to detect apoptosis in myocardial cells.
- Examined CPP-32 expression through immunohistochemical techniques.
- Apoptosis was found in six of the eight patients with arrhythmogenic right ventricular dysplasia, while absent in controls.
- High expression levels of CPP-32 correlated with positive DNA fragment labeling.
Structured PICO
P
Population
Autopsy specimens from the right ventricular myocardium of 8 patients with arrhythmogenic right ventricular dysplasia and 4 age-matched normal subjects.
C
Comparator
Autopsy specimens from 4 age-matched normal subjects.
O
Outcome
Presence of apoptosis (identified by in situ end-labeling of fragmented DNA) and expression of CPP-32.surrogate
Apoptosis is present in the right ventricular myocardium of patients with arrhythmogenic right ventricular dysplasia and may contribute to progressive myocardial cell loss.
Cite This Study
Mallat et al. (1996) studied this question.