January 1, 2000Japanese Heart JournalOpen Access

Apoptotic Cell Death in Arrhythmogenic Right Ventricular Cardiomyopathy. A Comparative Study with Idiopathic Sustained Ventricular Tachycardia.

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Why the study?

Does apoptotic cell death occur more frequently in the right ventricular myocardium of patients with ARVC compared to those with idiopathic sustained VT?

Population

79 patients, including 37 with Arrhythmogenic Right Ventricular Cardiomyopathy, 30 with idiopathic sustained…

Design

Case-control

Authors

MNMakoto NagataSaitama Medical University Hospital MHMichiaki HiroeCardiac Imaging SIShigeru IshiyamaTokyo Medical and Dental University

Discussion

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Implication

Elevated apoptosis may drive myocyte loss in ARVC beyond VT effects; supports mechanistic research but remains hypothesis-generating.

Structured PICO

Does apoptotic cell death occur more frequently in the right ventricular myocardium of patients with ARVC compared to those with idiopathic sustained VT?

Population

79 patients, including 37 with Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) (2 autopsied, 35 biopsied), 30 with idiopathic sustained ventricular tachycardia (VT), and 12 controls (5 autopsied non-cardiac, 7 biopsied with normal function).

Comparator

Idiopathic sustained ventricular tachycardia (VT) and normal controls

Outcome

Apoptotic cell death measured by in situ terminal deoxynucleotidyl transferase assay (TUNEL) and agarose gel electrophoresissurrogate

Apoptosis contributes to progressive myocyte loss in ARVC and is not merely a result of ischemia from repetitive ventricular tachycardia, as it is absent in idiopathic VT.

Limitations

Tiny biopsy samples from the septal endomyocardium may cause sampling error and underestimation of TUNEL-positive cells
Cell death may occur sporadically and periodically rather than persistently
Unable to determine ultrastructure

Cite This Study

Nagata et al. (2000) studied this question.

synapsesocial.com/papers/6a1f2edc0a715b28e072a8eb https://doi.org/10.1536/jhj.41.733

Topics

Ventricular arrhythmias

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Apoptotic Cell Death in Arrhythmogenic Right Ventricular Cardiomyopathy. A Comparative Study with Idiopathic Sustained Ventricular Tachycardia.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Apoptotic Cell Death in Arrhythmogenic Right Ventricular Cardiomyopathy. A Comparative Study with Idiopathic Sustained Ventricular Tachycardia.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

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