January 7, 1997Circulation
Effects of Estrogen Replacement Therapy on the Renin-Angiotensin System in Postmenopausal Women
Key result
Estrogen replacement therapy in postmenopausal women was associated with significantly lower renin levels (12.0 vs 16.6 mU/L; P=0.001) compared to women without ERT.
Why the study?
Does estrogen replacement therapy alter the components of the renin-angiotensin system in postmenopausal women?
Population
672 individuals from a population-based sample, including postmenopausal women with estrogen replacement…
Comparison
Estrogen replacement therapy (oral or transdermal) vs Postmenopausal women without estrogen…
Design
Cross-sectional
Authors
Discussion
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Implication
Should not yet influence ERT decisions; leaves open RAS-mediated effects on outcomes.
Study Design
Type
Observational (n=672)
Structured PICO
Does estrogen replacement therapy alter the components of the renin-angiotensin system in postmenopausal women?
P
Population
672 individuals from a population-based sample, including postmenopausal women with estrogen replacement therapy (n=107), postmenopausal women without estrogen replacement therapy (n=223), and age-matched men (n=342).
I
Intervention
Estrogen replacement therapy (oral or transdermal)
C
Comparator
Postmenopausal women without estrogen replacement therapy and age-matched men
O
Outcome
Levels of renin, angiotensinogen, ACE activity, and aldosteronesurrogate
Main Result
Absolute Event Rate: 12% vs 16.6%
p-value: p=.001
Estrogen replacement therapy in postmenopausal women is associated with a substantial suppression of renin alongside the known induction of angiotensinogen.
Cite This Study
Schunkert et al. (1997) conducted an observational in Postmenopausal women (n=672). Estrogen replacement therapy (ERT) vs. Women without ERT and age-matched men was evaluated on Renin levels (p=.001). Estrogen replacement therapy in postmenopausal women was associated with significantly lower renin levels (12.0 vs 16.6 mU/L; P=0.001) compared to women without ERT.