Key result
In vitro aspirin administration showed a significantly greater inhibitory effect on spontaneous platelet aggregation in men compared to women (inhibitory ratio 1.54 vs 1.23; p<0.001).
Why the study?
Does the in vitro inhibitory effect of aspirin on platelet aggregation differ between men and women, and is it influenced by testosterone?
Population
Men, women, and male patients with carcinoma of the prostate receiving hormone therapy (orchiectomized).
Comparison
In vitro aspirin vs Between sexes and hormone status
Design
Preclinical
Authors
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Sex differences in aspirin's platelet effects are hypothesis-generating; should not alter therapy without human confirmation.
Observational
Does the in vitro inhibitory effect of aspirin on platelet aggregation differ between men and women, and is it influenced by testosterone?
Absolute Event Rate: 1.54% vs 1.23%
p-value: p=<0.001
The antithrombotic effect of aspirin appears to be greater in men than women, potentially mediated by testosterone enhancing aspirin's inhibition of platelet aggregation.
Spranger et al. (1989) conducted an observational in Healthy individuals and prostate carcinoma. Aspirin (in vitro) vs. Women and orchiectomized men was evaluated on In vitro inhibitory effect of aspirin on spontaneous platelet aggregation (inhibitory ratio) (p=<0.001). In vitro aspirin administration showed a significantly greater inhibitory effect on spontaneous platelet aggregation in men compared to women (inhibitory ratio 1.54 vs 1.23; p<0.001).
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