A complete murine model of human diabetic kidney disease has yet to be validated by the AMDCC, though critical analysis of existing models enhances understanding of the disease process.
A complete murine model of human diabetic kidney disease has not yet been validated, though ongoing characterization efforts improve understanding of the disease process.
Diabetic nephropathy is a major cause of ESRD worldwide. Despite its prevalence, a lack of reliable animal models that mimic human disease has delayed the identification of specific factors that cause or predict diabetic nephropathy. The Animal Models of Diabetic Complications Consortium (AMDCC) was created in 2001 by the National Institutes of Health to develop and characterize models of diabetic nephropathy and other complications. This interim report and our online supplement detail the progress made toward that goal, specifically in the development and testing of murine models. Updates are provided on validation criteria for early and advanced diabetic nephropathy, phenotyping methods, the effect of background strain on nephropathy, current best models of diabetic nephropathy, negative models, and views of future directions. AMDCC investigators and other investigators in the field have yet to validate a complete murine model of human diabetic kidney disease. Nonetheless, the critical analysis of existing murine models substantially enhances our understanding of this disease process.
Brosius et al. (Fri,) conducted a review in Diabetic nephropathy. Murine models was evaluated. A complete murine model of human diabetic kidney disease has yet to be validated by the AMDCC, though critical analysis of existing models enhances understanding of the disease process.