Key result
Existing mouse models of diabetic nephropathy present with various features of the disease, but none develop renal changes that sufficiently reflect those seen in humans.
This review serves as a guide for selecting the most appropriate mouse model for investigating diabetic nephropathy.
Mouse models of diabetic nephropathy warrant cautious interpretation; leaves open the need for models that better reflect human renal pathology.
Diabetic nephropathy is the leading cause of end stage renal diseases worldwide. Even though several diabetic animal models exist, not a single one develops renal changes sufficiently reflecting those seen in humans. This review provides an overview on mouse models presenting with various features of diabetic nephropathy. The critical analysis and comparison of existing mouse models substantially enhances our understanding of the disease process and should provide a guide for choosing the most suitable mouse model for the investigation of diabetic nephropathy.
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Peters et al. (2012) conducted a review in Diabetic nephropathy. Mouse models was evaluated. Existing mouse models of diabetic nephropathy present with various features of the disease, but none develop renal changes that sufficiently reflect those seen in humans.
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