Key result
Sarcomeric protein mutations and modifications drive inherited and acquired cardiac disorders by altering pump function.
This review highlights the pathophysiological mechanisms of sarcomeric proteins in acquired and inherited heart diseases, emphasizing their potential as therapeutic targets.
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Positions sarcomeric proteins as potential therapeutic targets; leaves open clinical translation pending prospective validation.
Velden et al. (2018) conducted a review in Cardiac disorders. Mutations and posttranslational modifications of sarcomeric proteins fundamentally alter cardiac pump function, driving the pathophysiology of acquired and inherited cardiac disorders.
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