Key result
Sarcomeric dysfunction in heart failure largely originates from altered protein phosphorylation caused by neurohumoral-induced alterations in the kinase-phosphatase balance.
Population
Heart failure (animal models and human failing myocardium)
Design
Review
Authors
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Does not change practice; leaves open kinase-phosphatase modulation as a research target in HF.
Highlights the role of altered protein phosphorylation in sarcomeric dysfunction in heart failure, suggesting potential novel therapeutic targets.
Hamdani et al. (2007) conducted a review in heart failure. Sarcomeric dysfunction in heart failure largely originates from altered protein phosphorylation caused by neurohumoral-induced alterations in the kinase-phosphatase balance.
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