Key result
Ventricular tissue from patients with end-stage heart failure had significantly lower myofibrillar protein content and Mg-ATPase activity compared with normal hearts.
Authors
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May impair contractility in end-stage HF; leaves open causal role and need for mechanistic studies.
Observational
Pagani et al. (1988) conducted an observational in Heart failure (coronary artery disease, cardiomyopathy, mitral valve insufficiency). Ventricular tissue from patients with heart failure vs. Normal human ventricular muscle was evaluated on Myofibrillar content and myofibrillar Mg-ATPase activity. Ventricular tissue from patients with end-stage heart failure had significantly lower myofibrillar protein content and Mg-ATPase activity compared with normal hearts.
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