Key result
Transgenic expression of N-terminal-deleted cardiac troponin I in aged mice increased systolic and diastolic functions at 16 months of age compared with age-matched controls.
Why the study?
Does transgenic expression of N-terminal-deleted cardiac troponin I improve cardiac function in aged mice?
Population
Aged mice (16 months of age) and young transgenic mice
Comparison
Transgenic expression of N-terminal-deleted… vs Age-matched non-transgenic controls
Design
Preclinical
Follow-up
16 months of age
Authors
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May enhance aged cardiac function; hypothesis-generating for human therapies and should not change practice.
Does transgenic expression of N-terminal-deleted cardiac troponin I improve cardiac function in aged mice?
Removal of the cardiac troponin I N-terminal extension improves cardiac contractility and overall function in aged mice.
Biesiadecki et al. (2010) studied Cardiac dysfunction in aging. cTnI-ND transgenic expression vs. Age-matched non-transgenic controls was evaluated on Systolic and diastolic functions. Transgenic expression of N-terminal-deleted cardiac troponin I in aged mice increased systolic and diastolic functions at 16 months of age compared with age-matched controls.
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