Population
Cardiomyocytes isolated from transgenic mice expressing NH2-terminal truncated cardiac TnI or cardiac TnT…
Comparison
Expression of NH2-terminal truncated cardiac TnI… vs Wild-type control cardiomyocytes
Design
Preclinical
Authors
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Does not support clinical translation; leaves open troponin N-terminal modulation as a research target in human HF.
NH2-terminal truncations of cardiac troponin I and T produce distinct effects on cardiomyocyte contractility and calcium kinetics, demonstrating their roles in selectively modulating diastolic or systolic functions.
Wei et al. (2014) studied this question.
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