Population
In vitro models of cardiac troponin I (cTnI)
Comparison
Deletion or PKA phosphorylation of the… vs Unmodified cTnI
Design
Preclinical
Authors
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Should not yet influence clinical troponin-targeted therapies; extends molecular models of cardiac regulation in animal systems.
The NH2-terminal extension of cardiac troponin I regulates cardiac muscle function by modulating the molecular conformation and function of its core structure.
Akhter et al. (2011) studied this question.
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